krebs
With an objective to establish commercially viable biotech processes with applications in medicine, agriculture and industry, Krebs Biochemicals & Industries, a BioSpectrum Top 20 company, has made pioneering efforts in exploiting traditional microbial technology over the last decade.
Fermentation technology has been central to the growth of Krebs Biochemicals & Industries (KBIL). Its expertise in the fermentation process has led the company to manufacture a broad range of products in three categories-anti asthmatic drugs, nutraceuticals and statins.
Dr RT Ravi, managing director, KBIL, floated the company after his 14-year stint in this field. He gained valuable insights in a step-by-step process by first working as a scientist, then joining the industry as a researcher and later joining the corporate sector as a manager. After acquiring enough knowledge on how an industry runs, he jumped the bandwagon to start KBIL in 1991 and since then there has been no looking back.
Biochemical origins
The company went public in March 1994 and started the commercial production of Pseudoephedrine in 1994 at its Nellore facility. During the past ten years, the plant has been upgraded to manufacture about 300 tons per annum of Ephedrine, Pseudoephedrine and their salts. Consolidating its portfolio as a bulk drug manufacturer, Krebs later set another facility in Visakhapatnam for manufacturing cholesterol-reducing drugs like Lovastatin, Simvastatin and vitamin C. Another powerful statin, Pravastatin, is in the pipeline.
"We are
planning to enter the branded formulations market by next year"
What is the overall vision of
the company? What are the current
happenings at your R&D center at the ICICI Knowledge Park in Hyderabad? But as the size of the company grows bigger, we would want to be an R&D based company. Today what we are doing production outsourcing to technology companies elsewhere, which have big R&D centers. Talks are on with a UK-based company and we may start production for them in September. But precisely, our focus would on the R&D of new bio molecules and genetically engineered products by synthetic and biological approaches. Is the company planning to
diversify further in the health care segment after antiasthmatic drugs and
statins? What are the new products in the pipeline? To expand in the pharmaceutical segment it is important for us to have good manufacturing facilities and thereby we can license out the patent. So setting up of production base in India is vital. This way we can make the most of the indigenously available raw material and equally yield foreign exchange. The latest product in the pipeline is Pravastatin. This is prescribed to patients who have elevated levels of cholesterol that cannot be controlled through diet and exercise alone. The trial production is on and latest by next year, this would be out in the market. Krebs has recently ventured
into biofuels. How does the company foresee future growth in this segment? It is a totally unexplored area in our country and we are investing around Rs 70 crore on this project. We are optimistic about the outputs that this industry can reap. What has been the total biotech investment in the company till date and its plans for the future? The total biotech investment involved so far is around Rs 150 crore. And the turnover for the year 2003-04 stood at Rs 101.23 crore. We are targeting an aggressive growth rate to reach the Rs 500 crore mark in the next five to six years.
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KBIL exports its products to about 30 countries including the
US and Germany. Last year the company
obtained US FDA approval for three of its API (Active Pharmaceutical Ingredient)
drugs-Pseudoephedrine HCl, l-Ephedrine HCl and Pseudoephedrine Sulphate, which
will add further thrust to its exports. During the fiscal year 2003-04 Krebs
grossed a total turnover of Rs 101.23 crore, of which the biotech revenues were
to the tune of Rs 56.89 crore.
The company has a strong R&D focus. Presently its research center located at the ICICI knowledge park at Hyderabad aims at improving the product range and quality and developing alternate cost effective ways of manufacturing the existing products. Later as Krebs grows and diversifies its operations, it aims to focus on new biomolecules and genetically engineered products.
A wider canvas
While the company continues its pioneering efforts to be a significant international player in the bulk drugs product range, it also has identified other related growth areas of manufacturing in the post WTO regime. Thus, food processing, bio energy are major areas identified to develop as separate divisions of the company.
Biofuels
Leveraging its core competency in fermentation technology, KBIL is
diversifying into the bioagri segment. It has chosen biofuels and its downstream
products to catalyze growth. Krebs chose sugarcane as over other sources like
maize or potato for biofuel production due to the availability of bagasse, which
enables cheap power, a critical cost component in the fermentation process.
Elaborating further Dr Ravi said, "India despite being the second largest
grower of sugarcane has not been able to leverage sugarcane crop as source of
carbon due to not only the government restrictions but also because of the high
complexity of fermentation technology. A mastery over fermentation technology is
a must for extracting the carbon source or any other derivative from these
agricultural crops which can substitute any other synthetically produced product
or fossil fuel with industrial application".
To gain foothold in the sugar industry, it has participated in the privatization bid of Nannapaneni Venkat Rao Co-operative Sugars Ltd. Jampani, Andhra Pradesh and gained possession in December 2003. It has successfully completed the crushing season 2003-04 by crushing 69,690 million tonnes of sugarcane. And in the current season, it aims at 2,00,000 million tonnes of sugarcane and plans to increase it further to 8,00,000 million tonnes by 2005-06. Talking about the expansion plans, Ravi said, "The present capacity of 1300 TCD (Tonnes Cane per Day) of sugar crushing is slated to expand to 5000 TCD by 2005-06 generating 2,25,000 million tons of bagasse to suit the requirement for 22.5 MW power plant."
The total cost envisaged for the expansion program is Rs 44 crore. The company is planning to adopt various possible measures for cane management and bring in trust among the farmers for growing sugarcane.
Ethanol Production
Equally, KBIL is also planning to manufacture ethanol by fermentation
from sugar bearing or scratch substrates using yeast. Ethanol could be blended
in various proportions in petrol. KBIL is foreseeing a definite and assured
market for utilization of ethanol as a fuel and it is proposing to invest about
Rs 9 crore.
Setting up of 22.5 MW co-generation
power plant:
The viability of sugar industry is linked with the setting up of the
co-generation power plant. This will run on bagasse, a sugarcane byproduct
produced at the sugar plant. The power generation will be partially used for
captive consumption and the balance will be sold to the third party, which
happens to be AP Transco. The capital expenditure envisaged for this plant is Rs
6 crore.
Future outlook
As part of diversification, the company is also foraying into
food industry. It has set up a plant in Gaganpahad Village, Rajendra
Nagar, Hyderabad, to manufacture stackable fabricated potato chips with a
capital outlay of Rs 22.2 crore with a capacity of 300 kgs per hour. The plant
has a capacity to manufacture 2500 million tons chips per annum. "The
prospects from the project are lucrative with a projected turnover of Rs 80
crore per annum," admitted Ravi.
"The trial productions are through, and we are looking for a suitable marketing agency. We might be in the market anywhere between November 2004 to January 2005. The final product would be sold domestically and also exported," he added.
CyberMedia News, Hyderabad