Cipla USA furthers AMR stewardship with acquisition of key anti-infective ZEMDRI™ (IV Plazomicin)
Acquisition consistent with Cipla’s legacy of pioneering contribution to global healthcare challenges, industry leadership in anti-microbial resistance (AMR) stewardship practices and expertise in manufacturing, marketing and educational programs in the anti-infective segment
Cipla USA Inc. a wholly-owned subsidiary of the leading global pharmaceutical company Cipla Limited has announced the acquisition of the prescription drug ZEMDRI™ (Plazomicin) from Achaogen Inc. (“Achaogen”) in a Chapter 11, U.S. Bankruptcy Code auction of Achaogen’s assets. Cipla USA has acquired worldwide rights of ZEMDRI™ (excluding Greater China) with its allied assets and limited liabilities.
ZEMDRI™ is a once-daily novel intravenous (IV) aminoglycoside for the treatment of complicated urinary tract infections (cUTI), including pyelonephritis, in adults who are unresponsive to currently available treatment options. ZEMDRI™ was approved by the United States Food & Drug Administration (USFDA) in June 2018, and was launched in the same year, with patent protection expected to continue until 2031 or 2032. It has been granted a new technology add-on payment (NTAP) by the Centers for Medicare & Medicaid Services (CMS), for its administration in a hospital in-patient setting. The product has also been filed for approval in the European Union (EU).
ZEMDRI™ is the latest milestone in Cipla’s history of proactive and humanitarian leadership in enabling access to life-saving drugs. In 2001, at the height of the global HIV movement, Cipla changed the treatment paradigm with its offer of a triple combination anti-retroviral therapy at less than a dollar a day in Africa against the prevailing price of around USD 12,000 a year for one patient. With anti-microbial resistance (AMR) today being an urgent global healthcare challenge, Cipla has been at the forefront of AMR stewardship.
Plazomicin is a novel antibiotic effective against some of the cUTI-causing gram-negative bacteria that are resistant to beta-lactam antibiotics including carbapenems. Clinical studies have shown sustained microbiological eradication of the bacteria with Plazomicin.
Cipla is a signatory to the Industry Declaration on AMR at the World Economic Forum in Davos in 2016 that laid out a roadmap to combat AMR. More recently, Cipla introduced the extremely effective antibiotic colistin in India.
