21 July 2017 | News
Its properties were successfully tested in sealing a liver puncture and in conducting operations in moving organs, like lung and limbs.
Researchers at the Center for Nanoparticle Research, within the Institute for Basic Science (IBS) in collaboration with medical doctors in Seoul National University Hospital, created a surgical glue that is both adherent and visible in the most common imaging techniques: fluoroscopy, ultrasound, and computed tomography (CT).
It is the first nanoparticle-based tissue adhesive that features these characteristics. Its properties were successfully tested in sealing a liver puncture and in conducting operations in moving organs, like lung and limbs.
IBS scientists in collaboration with researchers at Kookmin University and Seoul National University Hospital designed nanoparticles with a shell made of silica (SiO2) and a core of radiopaque tantalum oxide (TaOx). SiO2 holds the tissue together, while TaOx provides contrast enhancement on ultrasound and CT.
The research team tested the TaOx/SiO2 core/shell nanoparticle (TSN) glue and found that it is clearly visualized by real-time imaging modalities and exhibits adhesive properties similar to that of the U.S. Food and Drug Administration (FDA)-approved cyanoacrylate and Lipiodol (CA-Lp), a mixture of a tissue adhesive and radiopaque oil used in the clinical practice.
This is important because it could help surgeons to recognize a moving surgical target and perform a safe and accurate operation.