Tuesday, 12 December 2017

Achievement of Biotech Company: Treat Burns with Pineapples

24 November 2017 | News

The company’s flagship product is a pineapple enzyme-based treatment used for the removal of dead tissue from burn wounds called NexoBrid.

Nasdaq-listed, Israel-headquartered biotechnology company MediWound Ltd. is attempting to revolutionize the way doctors treat second and third-degree burns.

To do so, it is using a patented technology first discovered by a German military doctor during the Second World War, which involves the topical application of pineapple plant enzymes to burn wounds. 

Founded in 2001 in Yavne, 18 miles south of Tel Aviv, MediWound develops, manufactures and commercializes treatments for severe burns and chronic wounds.

The company’s flagship product is a pineapple enzyme-based treatment used for the removal of dead tissue from burn wounds called NexoBrid.

The gel preparation kit is compiled of two vials, one containing enzymes from powdered pineapple tree trunks, the other containing a water-based gel. The two are designed to be combined just before application on the skin. The gel is effective in removing only the dead tissue, possibly minimizing the need for surgical procedures. 

MediWound CEO Gal Cohen narrates that, German military doctor called Jerry Klein who was stationed in North Africa in World War Two. In US He met an American doctor, and the two began collaborating in the research of the medicinal properties of pineapple enzymes when applied to burns. 

The research evolved throughout the 1960s and 1970s, but the two were unable to isolate and control the levels of enzymes well enough to assure a consistent, marketable medication can be produced.

Israeli plastic surgeon Lior Rosenberg took on Mr. Klein’s research after meeting him at a conference in Switzerland in the 1980s. For over two decades Mr. Rosenberg researched and experimented with pineapple enzyme-based treatments and in 2001 he founded MediWound.

“It took us 12 years from the moment we founded the company to receive marketing approval,” Gal Cohen, Mediwound CEO said. NexoBrid was approved for marketing in Europe in 2012 and Israel in 2013. 

NexoBrid is intended as a replacement for surgical procedures. There are no other non-surgical treatments that achieve what NexoBrid does, Mr. Cohen said. Since the 1970s, doctors learned that the only way to treat severe burns is to surgically remove the dead tissue. “We are trying to change a medical paradigm, and that is a great challenge,” Mr. Cohen added. 

NexoBrid had its moment in the spotlight in October 2015, when more than 150 people suffered severe burns following a fire at a Bucharest, Romania nightclub. MediWound sent two doctors and a supply of NexoBrid kits to aid local doctors.

“The aid Mediwound sent Romania was practical proof of NexoBrid’s ability to serve as a central treatment for multi-casualty events,” said Mr. Cohen, who added that NexoBrid was used to treat over 50 burn victims in just three days. 

More than half of the burn centers in European hospitals now use NexoBrid, Mr. Cohen said.In January, Mediwound announced its expansion into Latin America through an exclusive agreement with Avalon Pharmaceutical S.A.

 MediWound will announc an agreement with Taiwanese biotech company Holy Stone Healthcare, Co., Ltd. for the distribution of NexoBrid in Taiwan. The companies plan to commercialize NexoBrid in Taiwan after getting regulatory approvals, expected to be granted within two years.

 “This agreement is part of our strategy to expand the use of NexoBrid to international markets by collaborating with local companies that take the responsibility for and possess the expertise in local regulatory, market access and marketing efforts,” said Gal Cohen.

 “Evidenced-based clinical studies and growing experience reported by numerous experts treating patients in routine and mass casualty events demonstrate that NexoBrid will play a major role in the future of burn care,” said Albert Wu, Chief Executive Officer of Holy Stone. 

In addition to Europe and South America, NexoBrid is also marketed in Japan, South Korea, and India.

 MediWound still awaits FDA approval. The company expects to begin a U.S. Phase III clinical trial and a pediatric Phase III study next year. All of NexoBrid U.S. research and registration process is funded by federal agency Biomedical Advanced Research and Development Authority (BARDA). In July, BARDA increased the funding for MediWound by $32 million, for a total of $56 million.

 Mr. Cohen suggests that the main challenges NexoBrid is facing are the slow pace in which treatment protocols get changed, and the bureaucracy involved in obtaining insurance coverage for the drug. Still, he said, there is no surgical capacity to treat burn victims from multiple casualty incidents, not in Israel or anywhere else in the world, which should ultimately spell success for MediWound. 

Oppenheimer & Co Inc.’s biotech analyst Akiva Felt agrees and said “NexoBrid is well positioned to gain a substantial share of the burn treatment market, due to its many advantages and its impressive clinical effectiveness”.

 

 

 

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