Russian scientists have proposed a new kind of cancer treatment based on nanoparticles which induce more damage to cancer cells than conventional treatments and may even work on cells which are resistant to drugs.
The nanoparticles are made from an enzyme called cytochrome (Cyt), and cardiolipin (CL), a key part of a cell's inner mitochondrial membrane.
Researchers from Moscow State University, Northeastern University in Boston and the Russian Academy of Sciences demonstrated that the nanoparticles stimulate the death of cancer cells by acting on the cell membrane and/or mitochondrial membrane.
This new type of anticancer nano-formulation based on the catalytic action of Cyt-CL nanoparticles results in lipid peroxidation reactions, which give rise to activation of apoptosis (cell death) in cancer cells, including multidrug resistant cells. The effect of existing anti-cancer therapies is based mainly on the stimulation of apoptosis in cancer cells.