Artificial mouse ‘embryo’ created from stem cells for first time

They used a combination of genetically-modified mouse ESCs and TSCs, together with a 3D scaffold known as an extracellular matrix and created a structure capable of assembling itself and whose development and architecture very closely resembled the natural

stem-cells

Researchers from the University of Cambridge in the UK have successfully created artificial mouse embryos in lab, using a 3D scaffold and the body's master stem cells, an advance that may explain why more than two out of three human pregnancies fail.

They used a combination of genetically-modified mouse ESCs and TSCs, together with a 3D scaffold known as an extracellular matrix and created a structure capable of assembling itself and whose development and architecture very closely resembled the natural embryo.

The stem cells organise themselves, with ESCs at one end and TSCs at the other. A cavity opens them up within each cluster before joining together, eventually to become the large, pro-amniotic cavity in which the embryo will develop. The study was published in the journal Science.

Magdalena Zernicka-Goetz from Cambridge, who led the research said, "Both the embryonic and extra-embryonic cells start to talk to each other and become organised into a structure that looks like and behaves like an embryo. It has anatomically correct regions that develop in the right place and at the right time. Researchers found a remarkable degree of communication between the two types of stem cell: in a sense, the cells are telling each other where in the embryo to place themselves."

She also added, "We knew that interactions between the different types of stem cell are important for development, but the striking thing that our new work illustrates is that this is a real partnership-these cells truly guide each other. Without this partnership, the correct development of shape and form and the timely activity of key biological mechanisms doesn't take place properly. Comparing the artificial ‘embryo' to a normally-developing embryo, the team was able to show that its development followed the same pattern of development."

Leave a Reply Sign in

Notify me of follow-up comments via e-mail address

Post Comment

BusinessWire India.com - Healthcare & biotechnology

Bwi-logo

Philip Morris International Announces €300 Million Investment in Smoke-Free

Wednesday, 22 Mar 2017   |   Philip Morris International

Business Wire India Converting existing cigarette factory in Greece into a production facility for

Masimo Announces CE Marking of Rad-97™ Pulse CO-Oximeter® and Connectivity

Tuesday, 21 Mar 2017   |   Masimo

Business Wire India Masimo (NASDAQ: MASI) announced the CE marking of noninvasive blood pressure (NIBP)

Boehringer Ingelheim Phase III study now enrolling patients with progressive

Monday, 20 Mar 2017   |   Boehringer Ingelheim

Business Wire India For the first time, patients with different fibrosing lung diseases will be included

BusinessWire India.com - Pharmaceutical

Bwi-logo

Masimo Announces CE Marking of Rad-97™ Pulse CO-Oximeter® and Connectivity

Tuesday, 21 Mar 2017   |   Masimo

Business Wire India Masimo (NASDAQ: MASI) announced the CE marking of noninvasive blood pressure (NIBP)

Boehringer Ingelheim Phase III study now enrolling patients with progressive

Monday, 20 Mar 2017   |   Boehringer Ingelheim

Business Wire India For the first time, patients with different fibrosing lung diseases will be included

Uninterrupted Pradaxa® Showed Less Major Bleeding than Warfarin in Atrial

Monday, 20 Mar 2017   |   Boehringer Ingelheim

Business Wire India In the RE-CIRCUIT® trial, there were less major bleeding and fewer serious adverse

BusinessWire India.com - Medical Devices

Bwi-logo

Masimo Announces CE Marking of Rad-97™ Pulse CO-Oximeter® and Connectivity

Tuesday, 21 Mar 2017   |   Masimo

Business Wire India Masimo (NASDAQ: MASI) announced the CE marking of noninvasive blood pressure (NIBP)

Survey Box

Union Budget

Has Union budget 2017 addressed all requirements of healthcare industry?

Send this article by email

X