Manipal University research received yet another shot in the arm when a team led by Dr Satish Adiga and Dr. Hanudatta Atreya of Indian Institute of Science (IISc) Bangalore identified a way to predict DNA defects in IVF derived early embryos using a noninvasive technology.
Last week, the University Researchers had discovered the biomolecules that impede surveillance against infection and promote complications in diabetes.
In this study, the researchers induced DNA lesions experimentally in mouse embryos and observed stark changes in embryo metabolism with high level of DNA damage.
The Nuclear Magnetic Resonance (NMR) technology was used to detect the metabolic changes in the surrounding growth medium of the embryos. The researchers could detect this change 24 hours before the onset of cell death in the embryos. This may prove to be extremely advantageous when extrapolated to the clinical IVF set up.
The team included Fiona D'Souza, Shubhashree Uppangala, Guruprasad Kalthur and scientists from IISC and National Centre for Biological Sciences (NCBS), Bangalore.