Photo Courtesy: www.eeagrants.org)
Mekinist (trametinib) is used in treating patients with unresectable or metastatic melanoma with BRAF (a gene) V600 mutation.
Trametinib has not demonstrated clinical activity in patients who have progressed on a prior BRAF inhibitor therapy.
Before taking trametinib, patients must have confirmation of a BRAF V600 mutation using a validated test.
Trametinib is a MEK inhibitor which blocks the activity of a protein kinase called MEK-1. This protein is present in the MAPK pathway, which regulates the normal growth and death of cells and plays a role in metastatic melanoma development.
Some mutations in the BRAF gene can cause the MEK protein to stimulate cancer cell growth and survival; therefore, inhibiting MEK can potentially slow down the growth of tumors in BRAF-mutant metastatic melanoma.