Stem Cells to address autoimmunity, cancer and bone anomalies soon

Tran-Scell Biologics Pvt. Ltd., Hyderabad, in collaboration with the Department of Biotechnology (DBT) is all set to bring at least 3 Stem Cell based technologies to clinical stage by 2015, addressing autoimmunity, cancer and bone anomalies.


Dental pulp MSCs (Mesenchymal Stem Cells) on Titanium implant

Tran-Scell Biologics is a private player in Stem Cell banking and research for applications in India. Its management team consists of a heterogeneous mixture of practicing clinicians, Stem Cell scientists and industry veterans.

All solutions or proposing healthcare solutions come from practicing clinicians at Tran-Scell's network, who are the end users themselves. One such problem in dentistry that was submitted to the company was periodontal diseases, which make patients chronically run down and fatigued by overloading their immune system, ultimately leading to organ dysfunctions.

The main objectives of the program were to establish an effective procedure for culturing MSCs (Mesenchymal Stem Cells) on 3 different implant materials namely, Titanium, Zirconium and Collagen; To compare attachment kinetics, proliferation rate, and synthesis of generationassociated proteins on all the three surfaces; To completely quantify bone and neuro specific periodontal components in the MIB (Mesenchymal Implant Bio-complex) cultures; To study the stability of the Stem Cell Implant bio-complexes - comparative SEM (FIB) evaluation of the Cell-implant surfaces.

Tran-Scell Biologics Pvt. Ltd., received the project support from SBIRI (Small Business Innovation Research Initiative) scheme, DBT, in December 2012. Tran-Scell has an established laboratory facility in Hyderabad, working on clinical grade Stem Cells, tissue engineering
aspects of scaffolding and formulating Cell types, for a potential integrated solutions in managing diseases.

The project's vision has been on managing debilitating diseases, than propagating single step magic cure, which is not the reality in global healthcare. The project on "Stem Cell Implant Biocomplexes for Periodontal Tissue Regeneration" was initiated in 2011 at Tran-Scell's
laboratory, Hyderabad.


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