NHL treatment pipeline shows below average innovation

Despite the difficulty of several targeted NHL (Non-Hodgkin Lymphoma) therapies in achieving improved efficacy rates, the development of such treatments remains of key interest across NHL


(Photo Courtesy: www.bradenkelley.com)

The product pipeline for NHL exhibits a lower degree of innovation than both the industry and oncology average, with just 28% of all pipeline products, or 33% of the pipeline for which there is a disclosed molecular target, categorized as first-in-class.

This is in comparison to industry, breast cancer and lung cancer innovation rates of 43%, 57% and 59%, respectively, says business intelligence provider GBI Research.

The company's latest report states that while NHL, collectively, is the sixth to tenth most common cancer dependent on territory, each individual subtype is classified as an orphan disease.

With significant differences in each subtype's genetic profile and current treatment, there is reduced scope for the development of a targeted therapy with cross-subtype activity.

This does not present NHL drug development as an attractive investment in comparison to other indications in oncology, particularly as survival durations across many NHL subtypes are relatively strong, and likely the reason for low first-in-class innovation levels.


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